{"id":780,"date":"2017-08-07T10:05:13","date_gmt":"2017-08-07T09:05:13","guid":{"rendered":"http:\/\/www.mub.eps.manchester.ac.uk\/in-abstract\/?p=780"},"modified":"2017-12-05T10:19:23","modified_gmt":"2017-12-05T10:19:23","slug":"the-control-of-important-radical-reactions","status":"publish","type":"post","link":"https:\/\/www.mub.eps.manchester.ac.uk\/in-abstract\/the-control-of-important-radical-reactions\/","title":{"rendered":"Enantioselective cyclizations and cyclization cascades of samarium ketyl radicals"},"content":{"rendered":"

Breakthrough in the control of important radical reactions<\/strong><\/p>\n

Enantioselective synthesis allows the 3D molecular architectures of society\u2019s drugs, agrochemicals and materials to be assembled. Many of the complex molecules we need also contain intricately linked rings of atoms and the rapid and selective generation of these structures is a major challenge. Domino sequences of ring-forming reactions involving radical intermediates could provide a breakthrough. Although there are many reagents that generate radicals, samarium diiodide (SmI2<\/sub>) is one of the most effective and is used worldwide. Unfortunately, carrying out reactions with radicals in enantioselective fashion remains challenging due to their high reactivity.<\/p>\n

Forty years since the introduction of SmI2<\/sub> as a reagent for synthesis, and thousands of publications later, the first use of a chiral ligand to control the selectivity of reactions using the reagent has been achieved thus allowing vital molecules to be made quickly and efficiently. Researchers at the University of Manchester have invented enantioselective radical cyclization reactions that exploit SmI2<\/sub> and a recyclable chiral ligand and convert simple feedstocks to complex polycyclic products with exquisite control of 3D shape. The study suggests that many synthetic processes that rely on SmI2<\/sub> can now be used for the enantioselective synthesis of society\u2019s most important molecules and materials.<\/p>\n

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